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It is often used in muscle spasms. 1 doctor answer • 1 doctor weighed in Dr. Get Back Your Independence & Freedom From The Aches & Pains of Everyday Life. Cyclobenzaprine is used short-term to treat muscle spasms. Cyclobenzaprine is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. Pharmacies to Help You Save on Prescription Costs..